Objective: To probe into the entry point of clinical pharmacists in providing postoperative pharmaceutical care for lower respiratory tract infection in children with complicated congenital heart disease supported by extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT). Methods: Clinical pharmacists participated into the postoperative anti-lower respiratory tract infection treatment of two children with complicated congenital heart disease respectively supported by ECMO and CRRT. By retrieving the literature

the pharmacokinetic characteristics of different antibiotics under ECMO and CRRT were clarified

and recommendations and guidance were provided for the correct selection and rational use of antibiotics in children. Results: The clinicians adopted the suggestions of the clinical pharmacists and adjusted the anti-infective treatment plan

the infection indicators of two children were significantly improved. Conclusion: The application of ECMO and CRRT can affect the pharmacokinetic parameters of antibiotics

and conventional empirical medication may not achieve the goal. In-depth clinical practice

literature review

awareness of characteristics of antimicrobial PK/PD

analysis and formulation of medication recommendations in clinic pharmacists can help to provide ration treatment plans for children and improve the effectiveness and safety of clinical medication.