Objective: To compare the effects of high concentration oxygen therapy and titration oxygen therapy on percutaneous carbon dioxide partial pressure (PtCO2) in children with acute asthma. Methods: Totally 100 children with asthma aged from 2 to 18 years who were admitted to our hospital due to the moderate or severe asthma attack were selected to be randomly divided into the high concentration oxygen therapy group (HCOT group) or the titrated oxygen therapy group (TOT group). PtCO2 and asthma scores were measured at 0

20

40

60

and 90 min

and the admission rate of two groups were compared and analyzed. Results: At 60 min

the proportion of PtCO2 increased by >4 mm Hg and PtCO2 increased by >6 mm Hg in the HCOT group was significantly higher than that in the TOT group. The proportion of PtCO2 increased by >4 mm Hg and PtCO2 increased by >38 mm Hg in the HCOT group was significantly higher than that in the TOT group (P<0.05). The average elevation rate of PtCO2 in the HCOT group was higher than that in the TOT group

the asthma score was higher than that in the TOT group. The peak expiratory flow rate (PEFR) of HCOT group was higher than that of TOT group at 90 min (P<0.05). The admission rate in the HCOT group was 44.0% (22/50)

higher than that in the TOT group (30.0%

15/50)

yet the difference was not statistically significant (P>0.05). Conclusion: High concentration oxygen therapy in children with acute asthma can lead to a significant increase in PtCO2 levels

an increase in asthma scores

and an increase in admission rate. Therefore

in the treatment of acute asthma in children

it is not necessary to provide high concentration oxygen therapy for all patients

titration oxygen therapy can maintain the oxygen saturation of blood at more than 92%

which can simultaneously avoid hypoxemia and hypercapnia.