基于多元线性回归的癫痫患儿丙戊酸血药浓度影响因素分析

赖远花; 黄巧玉; 梁燕锦; 黄新伟; 李楚云; 唐尚鸿

doi:10.13407/j.cnki.jpp.1672-108X.2020.07.012

您当前的位置：

首页 >

文章列表页 >

基于多元线性回归的癫痫患儿丙戊酸血药浓度影响因素分析

论著（儿科临床药学） | 更新时间：2022-11-03

- 基于多元线性回归的癫痫患儿丙戊酸血药浓度影响因素分析
- Influencing Factors of Serum Valparaiso Acid Concentration in Children with Epilepsy Based on Multiple Linear Regression
- 儿科药学杂志 2020年26卷第7期页码：37-39
- 作者机构：
  
  1. 惠州市中心人民医院,广东,惠州,516001
  2. 惠州市第一人民医院,广东,惠州,516003
- 作者简介：
- 基金信息：
  
  2017 年度惠州市医疗卫生类科技计划项目,编号2017Y034
- DOI：10.13407/j.cnki.jpp.1672-108X.2020.07.012
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-7-10，
扫描看全文
赖远花, 黄巧玉, 梁燕锦, 等. 基于多元线性回归的癫痫患儿丙戊酸血药浓度影响因素分析[J]. 儿科药学杂志, 2020,26(7):37-39.

Lai Yuanhua, Huang Qiaoyu, Liang Yanjin, et al. Influencing Factors of Serum Valparaiso Acid Concentration in Children with Epilepsy Based on Multiple Linear Regression[J]. 2020,26(7):37-39.
赖远花, 黄巧玉, 梁燕锦, 等. 基于多元线性回归的癫痫患儿丙戊酸血药浓度影响因素分析[J]. 儿科药学杂志, 2020,26(7):37-39. DOI： 10.13407/j.cnki.jpp.1672-108X.2020.07.012.

Lai Yuanhua, Huang Qiaoyu, Liang Yanjin, et al. Influencing Factors of Serum Valparaiso Acid Concentration in Children with Epilepsy Based on Multiple Linear Regression[J]. 2020,26(7):37-39. DOI： 10.13407/j.cnki.jpp.1672-108X.2020.07.012.

摘要

目的：探讨影响癫痫患儿丙戊酸（VPA）的血药浓度的因素。方法：回顾性分析我院218例VPA血药浓度监测报告，包括患儿性别、年龄、丙戊酸钠日总剂量、联合用药情况、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血浆白蛋白、血肌酐和稳态血药浓度。利用多元线性回归分析影响VPA血药浓度变化的因素。结果：多元线性回归分析显示，日总剂量与血药浓度呈正相关（P<0.05），白蛋白含量与血药浓度呈负相关（P<0.05），不同剂型对血药浓度有影响，丙戊酸钠缓释片与糖浆的血药浓度比较差异有统计学意义（P<0.05）。结论：丙戊酸钠的不同剂型、给药剂量和白蛋白含量会影响VPA血药浓度，患儿性别、年龄、是否联用左乙拉西坦或拉莫三嗪、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血肌酐与血药浓度无相关性

Abstract

Objective: To probe into the influencing factors of serum valparaiso acid (VPA) concentration in children with epilepsy. Methods: Retrospective analysis was performed on reports of 218 cases of VPA concentration monitoring in our hospital

including gender

age

total daily dose of valproate

drug combination

alanine aminotransferase

aspartate aminotransferase

plasma albumin

serum creatinine and steady-state serum concentration. Multivariate linear regression analysis was used to analyze the factors affecting the changes of VPA. Results: Multivariate linear regression analysis showed that the daily total dose was positively correlated with the serum drug concentration (P<0.05)

the total protein content was negatively correlated with the serum drug concentration (P<0.05). Different dosage forms had various influences on serum concentration

and the difference in serum concentration between valproate delayed-release tablets and syrup was statistically significant (P<0.05). Conclusion: VPA concentration is influenced by different dosage forms

dosage and total protein content of sodium valproate. There is no correlation between serum concentration and gender

age

drug combination with levetiracetam or lamotrigine

alanine aminotransferase

aspartate aminotransferase and serum creatinine

关键词

多元线性回归血药浓度丙戊酸

Keywords

multivariate linear regressionrug concentrationalproic ac

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

β-氧化代谢基因多态性与癫痫患儿丙戊酸肝毒性的相关性