Objective: To probe into the efficacy of salbutamol and ipratropium bromide combined with magnesium sulfate in the treatment of children with acute attack of bronchial asthma. Methods: Totally 106 children with acute attack of bronchial asthma admitted into our hospital from Mar. 2018 to Feb. 2019 were extracted to be divided into the control group and the observation group via the random number table

with 53 cases in each group. The control group was treated with aerosol inhalation of ipratropium bromide combined with salbutamol

while the observation group received aerosol inhalation of ipratropium bromide combined with salbutamol and intravenous injection of magnesium sulfate. The clinical efficacy

pulmonary function index

serological index and adverse drug reactions of two groups were observed. Results: The total effective rate of the observation group was higher than that of the control group (P<0.05). The disappearance time of wheezing

shortness of breath

cough and other symptoms

the length of stay in the observation group were shorter than those in the control group (P<0.05). After treatment

the first-second forced expiratory volume (FEV1) and maximum expiratory peak flow rate (PEF) in two groups were significantly higher than those before treatment

and the improvement of all indicators in the observation group was more significant (P<0.05). After treatment

the levels of immunoglobulin E (IgE) in two groups were significantly lower than those before treatment

and the reduction in the observation group was more significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions between two groups (P>0.05). Conclusion: Salbutamol

ipratropium bromide combined with magnesium sulfate in the treatment of acute attack of bronchial asthma in children is significantly better than salbutamol combined with ipratropium bromide

which can improve the clinical efficacy

shorten the improvement time of clinical symptoms

reduce the levels of IgE and improve patients’ pulmonary function.