Objective: To analyze the incidence of dyslipidemia in children with systemic lupus erythematosus (SLE) and related factors. Methods: A total of 180 children with SLE admitted into our hospital from Jan. 30th

2018 to Jun. 30th

2019 were extracted

and 50 children with healthy physical examination in our hospital were selected as the control group. The serum lipid level of all children were detected. According to the presence or absence of lipid metabolism disorder

children with SLE were divided into the lipid metabolism disorder group and the non-lipid metabolism disorder group. The clinical data and characteristics of two groups were compared

and the related factors of lipid metabolism disorder were analyzed. Results: The levels of low-density lipoprotein cholesterol (LDL-C)

very low-density lipoprotein cholesterol (VLDL-C)

triglycerides (TG)

and total cholesterol (TC) in children with SLE were higher than those in the control group

and the levels of high-density lipoprotein cholesterol (HDL-C) were lower than those in the control group

the difference was statistically significant (P<0.05). There were 130 SLE children with lipid metabolism disorder

with an incidence of 72.2%. Thrombus

coronary artery involvement

elevated C-reactive protein (CRP)

increased erythrocyte sedimentation rate

hypoalbuminemia

and positive anti-DSDNA antibody in the lipid metabolism disorder group were higher than those in the non-lipid metabolism disorder group

with statistically significant differences (P<0.05). There was no significant difference in age

gender

butterfly erythema

discoid erythema

arthritis

hair loss

photoallergic

oral ulcer

serositis

neuropsychiatric lupus

C3 reduction

C4 reduction

urine protein positive

elevated uric acid

positive anti-SSA antibody

positive anti-SSB antibody

positive ACL-IGM and positive ACL-IGG between two groups (P>0.05). Multivariate analysis showed that coronary artery involvement

increased CRP and hypoalbuminemia were related factors of SLE lipid metabolism disorder (P<0.05). Conclusion: The incidence of lipid metabolism disorder is relatively high in children with SLE. Children with lipid metabolism disorder have elevated CRP and an higher probability of coronary artery involvement and hypoalbuminemia

which should be attached more importance.