Objective: To investigate the off-label drug use in pediatrics of a hospital in 2017

so as to promote the rational drug use in pediatrics. Methods: Retrospective analysis was conducted on pediatric outpatient and emergency prescriptions and inpatient medical orders in Fengcheng Hospital in 2017. Off-label drug use was judged according to the latest drug instructions

and statistical analysis was conducted on types

age of children and physician titles of off-label drug use. Results: In 2017

the proportion of off-label drug use in pediatric outpatient and emergency prescriptions and inpatient medical orders of our hospital was respectively 1.44% and 1.30%

including 32 kinds of oral drugs and 16 kinds of injections. Off-label drug use in pediatric outpatient and emergency prescriptions and inpatient medical orders mainly focused on without drug use information in children (70.95%

68.21%)

off-age drug use (10.24%

13.91%)

and over indications (8.30%

9.27%). The top five off-label drugs were vidarabine injection

meprednisolone injection

ribavirin injection

acyclovir and ambroxol injection. With the increase of age

the incidence of off-label drug use in outpatient and emergency prescriptions and inpatient medical orders decreased significantly (P<0.05)

and the higher the professional title

the higher the incidence of off-label drug use (P<0.05). Conclusion: There were off-label drug use in outpatient and emergency prescriptions and inpatient medical orders of Fengcheng Hospital. Therefore

standardized management of drug use and medical staff training should be strengthened to minimize or avoid off-label drug use and ensure the rationality and safety of drug use for children.