Objective: To investigate the distribution characteristics of polymorphism of rs37973 locus in GLCCI1 gene in children with asthma in Yunnan

so as to provide theoretical basis for the realization of individualized drug therapy for different regions

races and genotypes. Methods: A total of 157 children diagnosed as asthma in outpatient or inpatient department of Kunming Children’s Hospital from Nov. 2016 to Oct. 2018 were extracted. Fluorescence in situ hybridization (FISH) was used to detect genotype of rs37973 locus in GLCCI1 gene in children with asthma. Results: The polymorphism of rs37973 locus in GLCCI1 gene was 36 cases (23.0%) in GG type

77 cases (49.0%) in GA type and 44 cases (28.0%) in AA type. The distribution frequencies of allele G and A were 47.5% and 52.5%

respectively. The genotype distribution was basically consistent with Europe

South America

Southeast Asia

East Asia and parts of South Asia and parts of North America (P>0.05)

yet different from that of Africa

West Asia

Central America and parts of South Asia and parts of North America (P<0.05). Conclusion: The distributions of rs37973 locus in GLCCI1 gene in children with asthma may have regional and ethnic differences

and individualized drug therapy should be given for different regions and genotypes in clinical practice.