Objective: To investigate the influencing factors of times of bronchoscopic lavage therapy in refractory Mycoplasma Pneumoniae pneumonia (RMPP). Methods: Retrospective analysis was conducted on clinical data of 125 children with RMPP undergoing bronchoscopic lavage in our hospital from Jan. 30th

2016 to May 30th

2019. All children were divided into the single lavage group (n=85) and the multiple lavage group (n=40) according to the times of bronchoscopic lavage therapy. Application of glucocorticoids in two groups were recorded. The clinical manifestations and biochemical data were compared

and the influencing factors of multiple bronchoscopic lavage therapy in RMPP were analyzed. Results: The proportion of application of glucocorticoids in the multiple lavage group was lower than that in the single lavage group

and the difference was statistically significant (P<0.05). The heat duration ≥7 d

disease course ≥7 d

pleural effusion

bronchial obstruction

mucosal erosion

C-reactive protein (CRP)

lactate dehydrogenase (LDH) and neutrophil ratio (N) in the multiple lavage group were higher than those in the single lavage group

the difference was statistically significant (P<0.05). Multivariate Logistic regression analysis showed that the application of glucocorticoids at one week before lavage was the protective factor for the times of bronchoscopic lavage therapy

while the heat duration ≥7 d

CRP≥44 mg/L

LDH≥480 U/L

mucosal erosion and bronchial obstruction were risk factors for the times of bronchoscopic lavage therapy (P<0.05). Conclusion: There are many influencing factors for multiple bronchoscopic lavage therapy in RMPP. Early application of glucocorticoids is the protective factor for the times of bronchoscopic lavage therapy in RMPP

which can reduce the times of bronchoscopic lavage therapy .