Objective: To compare the application value of high flow nasal cannula (HFNC) and nasal continuous positive airway pressure (nCPAP) in respiratory support for severe bronchiolitis

so as to provide reference for the selection of clinical treatment regimen. Methods: A total of 90 children with severe bronchiolitis admitted into the pediatrics of our hospital from Dec. 2016 to Dec. 2018 were enrolled to be divided into the observation group and the control group via the random number table

with 45 cases in each group. After admission

two groups were given conventional comprehensive treatment to ensure the smoothness of respiratory tract. On this basis

the observation group was treated with HFNC

and the control group was given nCPAP. The respiratory rate

transcutaneous oxygen saturation (TcSO2)

respiratory distress clinical score system (CSS) score

arterial partial pressure of oxygen (PaO2) and other respiratory related indicators before treatment and after treatment of 24 h and improvement of clinical symptoms and signs before and after treatment were compared between two groups. Results: The respiratory rate and CSS score of two groups significantly decreased after treatment of 24 h

and the degree of reduction was more obvious in the observation group. TcSO2 and PaO2 of two groups significantly increased after treatment of 24 h

and the ascending range in the observation group was significantly larger than that in the control group. After treatment

clinical symptoms of cough

lung rales and lung inflammation were improved in both groups. The disappearance time of symptoms and signs in the observation group was significantly shorter than that in the control group

with statistically significant differences (P<0.05). Conclusion: HFNC in respiratory support for children with severe bronchiolitis can significantly improve the ventilation function and clinical symptoms. The therapeutic effects of HFNC are better than that of nCPAP

and the sample size could be enlarged for further observation.