Objective: To retrospectively analyze the etiological characteristics of appendicitis in children and the distribution of pathogenic bacteria

and investigate the application rationality of antibiotics. Methods: A total of 1

383 cases of children with acute appendicitis in Hebei Children’s Hospital admitted from Jan. 2013 to Dec. 2017 were collected. Clinical data and treatment effects were analyzed

and the prognosis of discharged children was followed up. Results: The average age of onset was 5 years and 9 months

and the male to female ratio was 1.88∶1. A total of 719 strains of pathogens were isolated

including 683 strains of G- bacteria (95.0%) and 35 strains of G+ bacteria (4.9%). The top three detected pathogens were respectively Escherichia coli of 589 strains (81.9%)

Pseudomonas aeruginosa of 56 strains (7.8%)

and Klebsiella pneumoniae of 12 strains (1.7%). E. coli was highly sensitive to imipenem

meropenem

amikacin

polymyxin

piperacillin/tazobactam

with the sensitivity rate of >95.0%. Conclusion: The most common bacteria in acute appendicitis were E. coli and different pathogens have different sensitivity to antibiotics. Therefore

bacterial culture and drug resistance analysis of the pus are beneficial to the rational use of drugs in clinical practice