Objective: To probe into the correlation between the polymorphism of N-methyl-D-aspartate receptor 2B (GRIN2B) rs1806201 and rs1805247 locus and efficacy of methylphenidate in the treatment of attention deficit hyperactivity disorder (ADHD) in children in Han nationality. Methods: Totally 100 children with ADHD admitted into Zhumadian Central Hospital from Jan. 2017 to Jan. 2019 were extracted to be treated with open-dose of methylphenidate for 2 to 4 weeks

so as to obtain the best therapeutic response. ADHD symptoms were assessed with the Attention Deficit Hyperactivity Disorder Diagnostic Scale Parent Version (ADHDDS-P). According to the scale score before and after treatment

the clinical efficacy was divided into remission

effectiveness

and inefficiency. TaqMan SNP genotyping technique was used to detect the polymorphism at rs1806201 and rs1805247 locus of GRIN2B gene. Results: After treatment

40 cases were relieved

25 cases were effective and 35 cases were ineffective. The clinical efficacy of TT and CT genotypes at rs1806201 locus of GRIN2B gene was better than that of CC genotype (P<0.05). However

there was no significant difference in the clinical efficacy of different genotypes of rs1805247 locus (P>0.05). After treatment

the attentional deficit score

hyperactivity impulse score and total score of ADHDDS-P in children with TT and CT genotypes at rs1806201 locus were higher than those in children with CC genotype (P<0.05)

while there was no significant difference in the deduction score of ADHDDS-P among children with different rs1805247 locus (P>0.05). Conclusion: The polymorphism of rs1806201 of GRIN2B gene is related to the clinical efficacy of methylphenidate

while polymorphism of rs1805247 of GRIN2B gene is not correlated with efficacy of methylphenidate. The TT and CT genotypes at rs1806201 locus of GRIN2B gene in children in Han nationality had better drug response to methylphenidate than CC genotype.