Objective: To investigate the efficacy and safety of different doses of ibuprofen in the treatment of very low birth weight infants with patent ductus arteriosus (PDA)

so as to provide reference for the treatment. Methods: A total of 180 children with PDA who were less than 37 weeks and less than 1

500 g in body mass in our hospital from Feb. 30

2017 to Apr. 30

2019 were enrolled. All patients were divided into the high-dose group and the low-dose group via the random number table

with 90 cases in each group. Children in the high-dose group received ibuprofen of 20 mg/kg on the 1st day

10 mg/kg on the 2nd day

and 10 mg/kg on the 3rd day. Children in the low-dose group received ibuprofen of 10 mg/kg on the 1st day

5 mg/kg on the 2nd day

and 5 mg/kg the 3rd day. If the first course of treatment failed

the second course of treatment was given

the second course of treatment was the same as the first. The PDA closure rate after treatment

the incidence of adverse drug reactions and mortality during treatment

and the diameter of pulmonary artery before and after treatment of two groups were observed. Results: There was no statistically significant difference in mortality and incidence of adverse drug reactions between two groups during treatment (P>0.05). After the first course of treatment

the success rate of PDA treatment in the high-dose group was higher than that in the low-dose group

and the failure rate of PDA treatment was lower than that in the low-dose group (P<0.05). There was no significant difference in the success rate of PDA treatment between two groups in the second course of treatment (P>0.05). There was statistically significant difference in the cumulative success rate of PDA treatment between two groups after two courses of treatment (P<0.05). After two courses of treatment

there was no statistically significant difference in the reopening rate of arterial catheter between two groups (P>0.05). Before treatment

there was no statistically significant difference in the inner diameter of pulmonary artery between two groups (P>0.05). After treatment

the inner diameter of pulmonary artery in two groups was lower than that before treatment (P<0.05). After two courses of treatment

the inner diameter of pulmonary artery in the high-dose group was lower than that in the low-dose group

and the difference was statistically significant (P<0.05). Conclusion: The efficacy of high-dose ibuprofen in the treatment of very low birth weight infants with PDA is better than that of low-dose ibuprofen

with higher safety.