Objective: To probe into the clinical significance of changes of platelet (PLT) in children with Kawasaki disease (KD) during acute and recovery period. Methods: Clinical data of hospitalized children with KD in our hospital in 2016 were retrospectively collected to investigate the relationship between changes of platelet during acute period and non-responsive intravenous gamma globulin (IVIG) treatment of KD and coronary artery disease (CAL)

the guiding significance on the application of low-dose aspirin during recovery period was analyzed. Results: A total of 808 children with KD were collected. There were 36 cases (4.46%) in non-responsive IVIG group and 772 cases (95.54%) in responsive IVIG group. The PLT count and platelet hematocrit (PCT) of children in non-responsive IVIG group were lower than those in responsive IVIG group

and the mean platelet volume (MPV) was higher than that in responsive IVIG group (P<0.05). There were 178 cases (22.03%) with CAL (CAL group) and 630 cases (77.97%) without CAL (nCAL group) during recovery period. Totally 420 cases in nCAL group took low-dose aspirin regularly were followed up. PLT count in 321 cases (76.43%) was lower than 400×109/L after 6 weeks

355 cases (84.52%) was lower than 400×109/L after 8 weeks

the difference was statistically significant (c2=8.76

P<0.05). PLT count in 371 cases (88.33%) was lower than 400×109/L after 12 weeks

compared with 8 weeks

the difference was not statistically significant (c2=2.60

P>0.05). Conclusion: Changes of PLT

PCT

and MPV during acute period may be related to non-responsive IVIG treatment

and have no significant relationship with CAL. For the majority of children with KD and without CAL or transient coronary dilatation

6 to 8 weeks of oral low-dose aspirin treatment is appropriate.