Objective: To systematically review the efficacy of probiotics in prevention of children with urinary tract infection. Methods: Databases were retrieved to collect randomized controlled trial (RCT) related to probiotics in prevention of children with urinary tract infection. The retrieval time was from the establishment of the database to Mar. 2019. After screening the literature according to the inclusion criteria and exclusion criteria

extracting the data and evaluating the methodological quality of the included literature

Meta-analysis was performed by using RevMan 5.3 software. Results: A total of seven RCT were collected

including 1

879 children

with 938 cases in the treatment group and 941 cases in the control group. The treatment group was given lactobacillus

bifidobacterium lactis and lactobacillus reuteri

while the control group received placebo and macrodantin. Meta-analysis results showed that there was no statistically significant difference between two groups in prevention of urinary tract infection [OR=0.89

95%CI: from 0.52 to 1.54

P=0.69]. Conclusion: According to current relevant research

probiotics have no significant advantage in prevention of urinary tract infection.