Objective: To investigate the compatibility stability of invert sugar injection and four commonly used antibiotics

and to reduce the medication errors

so as to provide basis for rational clinical application of drugs. Methods: High performance liquid chromatography (HPLC) was used to determine the drug content in the compatibility solution

changes of drug appearance

pH value

insoluble particles and content of four commonly used antibiotics such as cefathiamidine

cefoxitin sodium

cefmetazole sodium and clindamycin phosphate in 5% and 10% invert sugar injection and control solvent (5% glucose injection) were observed at different time points. Results: There were no significant changes in the properties and contents of four commonly used antibiotics when mixed with 5% and 10% invert sugar injection. The pH value of cefoxitin sodium and invert sugar injection showed an increasing trend after compatibility

and the longer time of placement

the higher pH of compatibility solution

which was consistent with the pH change trend of compatibility with 5% glucose injection. After the compatibility of cefathiamidine and invert sugar injection

the pH gradually decreased with prolonged placement time. The compatibility of clindamycin phosphate

cefmezole sodium and invert sugar injection was stable

the insoluble particles met the requirements

and there is no significant changes in appearance

pH value or content. Conclusion: Ceftiamidine

cefoxitin sodium

cefmezole sodium and clindamycin phosphate can be used in combination with invert sugar injection. It is recommended to use cefoxetine and ceftiamidine within 2 h after compatibility with invert sugar.