Objective: To investigate the advantages and disadvantages of sufentanil and remifentanil respectively combined with propofol. Methods: A total of 150 children undergoing general anesthesia surgery in our hospital from Mar. 2016 to Mar. 2017 were extracted

according to the serial number of general anesthesia surgery

all children were divided into the sufentanil group and the remifentanil group via the random number table

with 75 cases in each group. The sufentanil group received general anesthesia with sufentanil and propofol

while the remifentanil group was given general anesthesia with remifentanil and propofol. Systolic blood pressure (SAP)

diastolic blood pressure (DBP)

mean arterial pressure (MAP) and bispectral index (BIS) of two groups were observed and compared during anesthesia induction period such as before induction (T1)

after intravenous injection of sufentanil (remifentanil) (T2)

after intravenous injection of propofol (T3)

intubation (T4)

after intubation of 2 min (T5) and after intubation of 5 min (T6). Results: The DBP and MAP in the sufentanil group were better than those in the remifentanil group at T4 (P<0.05). There was no significant difference in BIS between two groups at each time point (P>0.05). The spontaneous respiratory recovery

limb movement recovery and extubation time of the sufentanil group were shorter than those of the remifentanil group (P<0.05)

the respiratory depression

restlessness

nausea and vomiting

and disturbance of consciousness were less than those in the remifentanil group (P<0.05). Conclusion: Compared with remifentanil

sufentanil combined with propofol can significantly improve the postoperative pain of children

meanwhile

the side effects such as respiratory depression are less. Therefore

the application of sufentanil combined with propofol has obvious advantages in children undergoing general anesthesia surgery.