Objective: To investigate the effects of sevoflurane on muscular relaxation time of rocuronium bromide in children undergoing craniotomy at different ages. Methods: Thirty-six children undergoing craniotomy in Tangshan People’s Hospital from Feb. 2015 to Jun. 2017 were extracted. According to the age

there were 16 cases in the 1 to 3 year group

12 cases in the 4 to 6 year group

and 8 cases in the >6 years group. Inhalation of sevoflurane was given for anaesthesia. After the end-expiratory concentration of sevoflurane stabilized at 1.3 times of minimum alveolar concentration (MAC) for 40 min

rocuronium bromide was injected intravenously at 0.6 mg/kg. The direct operation time

onset time of rocuronium bromide (from completion of administration to the disappearance time (T1) of the first muscle twitch )

in vivo action time (T1 from 0 to 90% time)

recovery index (T2 from 25% to 75% time)

clinical muscle relaxation time (T1 from 0 to 25% time)

peak time (T1 from 0 to 5% time)

and recovery time of T1/T4 ratio (TOFr) to 70% and 90% were recorded. Results: None of the three groups of children continued to be supplemented with rocuronium bromide

and there was no significant difference in bispectral index (BIS) at each time point among three groups after muscle relaxation calibration (P>0.05). There were no significant differences in direct operation time

onset time

peak time

clinical muscular relaxation time

recovery index

in vivo action time

TOFr 70% time

and TOFr 90% time among three groups (P>0.05). Conclusion: The effects of 1.3 times of MAC sevoflurane on the recovery time of muscular relaxation time of rocuronium bromide in children undergoing craniotomy at different ages were not statistically significant.