Objective: To investigate the application of propofol combined with remifentanil in total intravenous anesthesia for children undergoing laparoscopic surgery. Methods: Totally 400 children undergoing laparoscopic surgery in our hospital from Jun. 2015 to Jun. 2017 were extracted to be divided into the observation group and the control group via the random number table

with 200 cases in each group. The control group was treated with remifentanil combined with sevoflurane

while the observation group received remifentanil combined with propofol. Anaesthesia effects

onset time of anaesthesia

maintenance time of anaesthesia

hemodynamic indexes

recovery time of spontaneous respiratory

eye-opening time

extubation time and incidence of adverse drug reactions of two groups were compared. Results: The excellent rate of anesthesia in the observation group was 97.50%

while that in the control group was 98.50%

without any statistically significant difference (P>0.05). The onset time and maintenance time of anesthesia in the observation group were respectively (6.95±2.14) min and (48.23±11.25) min

compared with (6.73±2.28) min and (49.42±10.64) min in the control group

there was no statistically significant difference (P>0.05). There was no significant change in the mean arterial pressure

heart rate and arterial oxygen pressure after anesthesia between two groups (P>0.05)

and the difference was not statistically significant (P>0.05). Compared with the control group

the postoperative recovery time of spontaneous respiratory (5.19±1.87) min

eye-opening time (7.85±2.60) min and extubation time (9.56±2.94) min were shorter in the observation group (P<0.05). The total incidence of adverse drug reactions was 4.50% in the observation group and 10.50% in the control group

with statistically significant differences (P<0.05). Conclusion: The application of propofol combined with remifentanil in total intravenous anesthesia for children undergoing laparoscopic surgery can achieve the same anesthetic effect as that of remifentanil combined with sevoflurane. However

the safety of propofol combined with remifentanil in total intravenous anesthesia is higher

which can accelerate postoperative consciousness recovery and reduce adverse drug reactions.