Objective:To study the application of digital subtraction angiography(DSA) in the super-selective intra-arterial infusion as the neoadjuvant chemotherapy for oral squamous cell carcinoma.Methods:From January 2010 to February 2011

6 patients with T3 or T4 oral squamous cell carcinoma of the tongue in our department were chosen to undergo super-selective intra-arterial chemotherapy through the superficial temporal artery.However

failure of all cases were noticed.The reason for this was the external carotid artery variation causing the inverted insertation of catheter into the internal maxillary artery or the external maxillary artery without reaching lingual artery.Under local anesthesia STD125-26S microcatheter was super-selectively posted into lingual artery about 5～6 cm by via per cutem femoral artery puncture using DSA.The next day’carboplatin plus 5-fluorouracil’ lingual arterial infusion chemotherapy was started

and change of the primary foci

the postoperative complications

the toxic side effects of chemotherapy were observed.Results:In six patients

foci in 2 patients disappeared

and cancer cells were not found by biopsy or pathologic serial section cutting.Primary foci in other 4 patiens shrank more than 50% of their original sizes.No noticeable postoperative vascular accidental complications or wound infections were observed.Toxic side effects of chemotherapy were minimal.Conclusion:The application of super-selective arterial perfusion in the new adjuvant chemotherapy for oral squamous cell carcinoma is simple with less complications and side effects

which is especially suitable for patients with vascular variation causing failed implantation of superficial temporoparietal artery pump.