Objective:To compare the associations of Apolipoprotein B/Apolipoprotein A1 ratio(ApoB/ApoA1 ratio) and high sensitive C-reactive protein(hs-CRP) with insulin resistance(IR).Methods:426 non-diabetes Chinese were recruited.Weight

height

blood pressure

waist circumference

fasting plasma glucose(FPG)

fasting serum insulin(Fins)

blood lipids and hs-CRP were measured.HOMA index(HOMA-IR) was calculated.IR was defined as the upper quartile of HOMA-IR.Results:ApoB/ApoA1 ratio and hs-CRP were significantly higher in subjects with IR compared with subjects without(P<0.01).After adjustment for age

gender and waist circumference

line regression analysis found that ApoB/ApoA1 ratio was still the main influence factor of HOMA-IR [B(95%CI):0.27(0.06-0.48)

P=0.013];However

the partial regression coefficient of hs-CRP and HOMA-IR was no longer statistically significant.Compared to the subjects with low ApoB/ApoA1 ratio

those with high ApoB/ApoA1 ratio were 2.17 [OR(95%CI):2.17(1.33-3.54)

P=0.002] times more likely to be with IR;and Compared to the subjects with low hs-CRP

those with high hs-CRP were [OR(95%CI):1.78(1.09-2.92)

P=0.021] times more likely to be with IR.Conclusion:compared with hs-CRP

ApoB/ApoA1 ratio might be a better marker of IR in non-diabetic Chinese population.