Objective:To explore the changes of serum immunoglobulin E(IgE) and eosinophils(EOS) before and after budesonid inhalation in children with cough variant asthma and its significance.Methods:147 cases with cough variant asthma were selected from our hospital between Jan.2007 and Jan.2010.The patients were categorized into the budesonid treated group and control group.During the treatment

the patients of the 2 groups were followed up for 2 months to compare the IgE and EOS levels before and after treatment.Results:Before and after 2 months’ treatment

the serum total IgE of control group were(226.16±21.09) ng/L and(240.39±19.56) ng/L respectively.As to the treated group

the serum total IgE before and after 2 months’treatment were(255.48±23.67) ng/L and(169.00±15.72) ng/L respectively.There was significant difference in total IgE between before and after 2 months’treatment(P<0.01).Before and after 2 months’ treatment

the EOS of control group were(1.22±0.60)×109/L and(0.98±0.41)×109/L respectively

the treated group were(1.35±0.73)×109/L and(0.41±0.20)×109/L respectively.There was significant difference in EOS after treatment.(P<0.01).Conclusion:When treating cough variant asthma

budesonid inhalation can decrease serum total IgE.Detection of IgE and EOS can be of great importance in diagnosis and treatment of children with cough variant asthma.