Objective: To investigate the prognosis value of lactate clearance rate in patients with respiratory failure.Methods:12 h lactate clearance rate was detected in 83 patients with respiratory failure.We used Logistic regression analysis for the prognosis.Results:A total of 17 patients died(20.5%).The sex

age

type of disease was not statistically significant between survival group and death group(P>0.05);the admission APACHE Ⅱ score

pH value

PaO2

PaCO2

PaO2/FiO2

admission blood lactate and lactic acid 12h clearance rate were significant differences between two groups(P<0.05).The blood lactate was negative correlated with pH value

PaO2

PaO2/FiO2

and positively correlated with PaCO2

APACHE Ⅱ

while the 12h lactate clearance rates were more apparent with these factors.The mortality in high lactate clearance rate group was 13.0%

Vs 34.5% in low clearance rate group(χ2=5.365

P= 0.021).The low-clearance group had a higher risk of mortality

OR= 3.534

95% CI was 1.023~12.524.After Logistic regression multivariate adjustment

the OR was 2.782.Conclusion: The rate of lactate clearance in patients with respiratory failure could be used as an important indicator for prognosis.