LI Xian-dong. Inhibitory effects of wogonin on lung cancer A549 cell line in vitro[J]. Journal of Chongqing Medical University, 2011,36(7):790-793. DOI: 10.13406/j.cnki.cyxb.2011.07.005.
Objective:To study the inhibitory effect of wogonin on proliferation
invasion ability and pro-apoptotic activity in lung cancer A549 cell line.Methods:MTT chromatometry was employed to determine the influence of wogonin on proliferation of A549 cell.The apoptosis-promoting effect of wogonin on A549 cell was observed by morphological method.The changes of cell invasive ability in vitro were detected by Transwell assay.Results:Wogonin showed significant inhibitory effect on the proliferation and invasive activity of A549 cell line and the apoptosis-promoting effect on lung cancer cells.Conclusion:Wogonin can significantly inhibit proliferation and migration of lung cancer A549 cells and promote the apoptosis of A549 cell line.