Objective:To investigate the expression and clinical significance of Foxp3 in normal skin and tissues of different epidermis neoplasms and to identify the underlying relation between Foxp3 expression and clinico-pathological characteristics of epidermis neoplasms.Methods:Immunohistochemical staining was applied to detect the expression of Foxp3 in tissue samples of 15 cases of actinic keratosis

28 cases of Bowen’s disease

26 cases of cutaneous squamous cell carcinoma

and 8 cases of normal epidermal tissue.Results:Foxp3+ regulatory T cells and Foxp3 were both expressed in epidermis neoplasms and precancerous lesions but not in the normal epidermal tissue.There was no significant difference of Foxp3 expression between the SCC and BD samples(P>0.05)

while in the samples of AK

Foxp3 expression was significantly lower than that in BD and SCC samples(P<0.05).Conclusion: The expression level of Foxp3 in normal skin

precancerous lesions and malignant tumors

is in ascending order and is correlated with the development of epidermis neoplasms.