Objective:Experimental study of acutobin combined with heparin to rabbit inferior vena cava thrombosis

endothelial lesions and the risk of blood.Methods:The inferior vena cava thrombus model was established in 72 rabbits and they were randomly divided into three groups:heparin group(A)

group for combination of urokinase and heparin(B)

group for combination of acutobin and heparin(C)

each group including 24 rabbits.Drugs were administrated 3 days after thrombosis.Doppler ultrasound and endothelial injury scale of Vascular lesions were used to assess thrombolytic effect.Coagulation indexes were tested to assess the risk of blood

3

7

10 days after administration.Results:At different phase

the thrombolytic effect of B group and C group were better than A group

having significant difference(P<0.01).The thrombolytic effect of B group and C group were better

but it was no difference between two groups(P>0.05).The endothelial cell injury level of B group and C group were lighter than A group

having significant difference(P<0.01)

but it was no difference between two B group and C group(P>0.05).B group and C group compared with A group that the value of PT prolonged

FBG values decreased

with significant differences(P<0.01).B group compared with C group that the value of PT prolonged

FBG values decreased

with differences between B group and C group(P<0.05).Conclusion:Acutobin combined with heparin could effectively dissolve rabbit vena cava thrombosis

reduce endothelial injury

had a good effect of treatment and prognosis

with relatively small risk of blood.