Objective:To detect the microvessel density(MVD) in tissue of normal buccal mucosa

erosive and non-erosive oral lichen planus and buccal cancer;to observe the microvessel density changes in order to further explore the pathogenesis of oral lichen planus and provide reference treatment.Methods:A total of 40 cases of newly diagnosed patients were selected from December 2008 to March 2010 in the affiliated hospital of stomatology

Chongqing medical university

including 10 cases of erosive OLP

10 cases of non-erosive OLP and 10 cases of buccal cancer

and 10 cases of buccal injury wound tissue collected as a normal buccal mucosa specimens.Tissue sections were performed by using vascular endothelial cell markers CD34

S-P immunohistochemistry.The microvessel density was measured under the optical microscope

with SPSS software for statistical analysis.Results:The MVD data for buccal cancer

erosive OLP

non-erosive OLP

and normal buccal mucosa were 36.825 0±7.048 5

27.700 0±6.183 3

16.600 0±5.111 5

and 7.350 0±1.472 9 respectively;by rank sum test

the difference of MVD between the erosive OLP and normal buccal mucosa

buccal cancer and normal buccal mucosa

buccal cancer and non-erosive OLP groups had statistical significance(P <0.05).Conclusion:The MVD of erosive OLP and buccal cancer is much higher than that of normal oral buccal mucosa;there’s no significant difference in MVD between the erosive and non-erosive OLP;the microvessel density and the severity of OLP tissue are significantly correlated

which could be considered as an evaluating index for the treatment and prognosis of OLP

as well as the development of cancer.