Objective:To investigate the correlation between serum CA19-9 levels and type 2 diabetes mellitus(T2DM)

and to analyze the relationship between blood glucose(BG)

T2DM correlation factors and CA19-9 levels.Methods:This was a retrospective observation.120 inpatients with T2DM(group A)were recruited into this study

and 108 non-T2DM inpatient(group B)were used as controls.Routine tests were examined in both of two groups to exclude other diseases

which might be responsible for increased CA19-9.Patients with T2DM were classified as two subgroups according to HbA1c level.A1 subgroup was considered as BG controlled group(HbA1c≤7.0%)

and A2 subgroup was considered as BG uncontrolled group(HbA1c>7.0%).CA19-9 concentration was measured with the electro-chemiluminescence immunoassay.Data were analyzed by SPSS17.0 software packet

and independent samples t-test was used for simple correlation analysis and stepwise linear regression analysis.Results:The independent samples t-test analysis showed the CA19-9 level of A was higher than that of B(P<0.01);that of A1 was lower than that of A2(P<0.01).Correlation analysis showed positive correlation between HbA1c

duration of T2DM and CA19-9.Stepwise regression analysis showed a positive linear correlation between HbA1c and CA19-9.Conclusion:The positive rate of CA19-9 is correlated with T2DM.There is a significant linear correlation between CA19-9 and HbA1c.This study suggests that CA19-9 is one of reference marker for BG control.