Objective: To investigate the value of serum cystatin C(Cyst C) detection for renal damage staging in children.Methods: 79 children with renal diseases and 20 with non-renal diseases as control group were enrolled in this study.All patients were hospitalized < 24 h

and their Cyst C and SCr levels were detected.According to Schwartz formula

GFR was calculated

and renal function staging was performed.ROC curve and the area under the curve were used for the diagnostic evaluation.Results: Cyst C and SCr concentration increased gradually with CKD stage(P<0.05)

and GFR descended gradually with CKD stage(P <0.05)

while it had no statistically significant difference between the control group and the CKD l group(P>0.05).Cyst C

SCr and GFR concentrations were correlated.Cyst C and SCr had good effect on diagnosis of each CKD stage

and Cyst C was better

and AUC was the largest in Cyst C for diagnosis of CKD 2.The diagnostic values of Cyst C diagnosis of CKD 2

CKD 3

CKD 4 ~ 5 were 1.0 mg/L

1.5mg/L and 2.6 mg/L

respectively.Conclusion: Cyst C has very good diagnostic effect on renal damage staging in children;Cyst C for staging renal failure in children is better than SCr

and is especially satisfying in early stage.