SPARC在子宫颈鳞癌中的表达及其临床意义

邓婷; 周勤

doi:10.13406/j.cnki.cyxb.2011.03.022

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SPARC在子宫颈鳞癌中的表达及其临床意义

基础研究 | 更新时间：2024-01-17

- SPARC在子宫颈鳞癌中的表达及其临床意义
- Expression of SPARC in the squamous cervical carcinoma and its clinic significance
- 重庆医科大学学报 2011年36卷第3期页码：310-314
- 作者机构：
  
  重庆医科大学附属第一医院妇产科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.03.022
  中图分类号： R737.33
- 纸质出版日期：2011，
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[1]邓婷,周勤.SPARC在子宫颈鳞癌中的表达及其临床意义[J].重庆医科大学学报,2011,36(03):310-314.

DENG Ting, et al. Expression of SPARC in the squamous cervical carcinoma and its clinic significance[J]. Journal of Chongqing Medical University, 2011,36(3):310-314.
[1]邓婷,周勤.SPARC在子宫颈鳞癌中的表达及其临床意义[J].重庆医科大学学报,2011,36(03):310-314. DOI： 10.13406/j.cnki.cyxb.2011.03.022.

DENG Ting, et al. Expression of SPARC in the squamous cervical carcinoma and its clinic significance[J]. Journal of Chongqing Medical University, 2011,36(3):310-314. DOI： 10.13406/j.cnki.cyxb.2011.03.022.

摘要

目的:探讨富含半胱氨酸的酸性蛋白（Secreted protein acidic and rich in cysteine

SPARC）与子宫颈鳞状细胞癌（Squamous cervical carcinoma

SCC）的发展及浸润的关系。方法:采用免疫组化SP法检测18例正常子宫颈上皮（Normal cervical epithelium

NCE）、41例子宫颈上皮内瘤变（Cervical intraepithelial neoplasm

CIN）及72例组织中SPARC的表达

并分别检测CD34的表达。结果:从NCE到CIN到SCC组

SPARC的表达水平显著升高。在CIN组SPARC的表达随病变程度加重而升高;而SCC组中其与国际妇产科联盟（FIGO）分期、盆腔淋巴转移、浸润深度及脉管浸润有关

与组织学分级及年龄无关。从NCE到CIN到SCC组

CD34表达的微血管密度（Microvessel density

MVD）值显著升高

且与SPARC有相关性。结论:SPARC可能在SCC的发展及转移过程中其重要作用

可能成为判断宫颈病变生物学行为的一个重要指标。

Abstract

Objective:To explore the expression of secreted protein acidic and rich in cysteine(SPARC) and its relationship with invasion

metastasis and prognosis in cervical squamous cell carcinoma.Methods:The expression of SPARC

microvascular density(MVD) labeled by CD34 in 18 cases of normal cervical epithelium(NCE)

41 cases of cervical intraepithelial neoplasm(CIN) and 72 cases of squamous carcinoma of cervix(SCC) were detected by immunohistochemistry SP method.Results:The positive expression of SPARC protein increased remarkably from NCE to CIN and then to SCC accordingly(P=0.039).In CIN

the expression of SPARC was significantly positive in high-grade squamous intraepithelial lesions compared to light-grade intraepithelial lesions.In SCC

the expression of SPARC correlated with FIGO staging

pelvic lymph node metastasis.stroma involvement and intravascular infiltration(P<0.05)

but not correlated with patients age and histological grading(P>0.05).The MVD increased remarkably from NCE to CIN and then to SCC accordingly(P<0.05).The expression of SPARC protein in CIN and SCC was correlated with MVD

respectivel.Conclusions:SPARC may play an important role during the cancer invasion and metastasis

and may be a valuable marker in prognosis in cervical squamous cell carcinoma.

关键词

子宫颈肿瘤富含半胱氨酸的酸性蛋白CD34免疫组织化学

Keywords

cervical cancersecreted protein acidic and rich in cysteineCD34immunohistochemistry

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