Objectives: To evaluate lipid peroxidation as a predictor for disease activity by analyzing the lipid peroxidation and components of metabolic syndrome.Methods: Serum level of fasting blood glucose

aminotransferase

gamma-glutamyl transpeptidase

triglyceride

total cholesterol

lipoprotein

malonaldehyde

reduced and oxidated glutathione of 89 non-alcoholic fatty liver disease patients and 30 healthy controls were analyzed by biochemical assay.The relationships between these indexes were analyzed by using multiple linear regression analysis and Student’s t-tests.Results: Most non-alcoholic fatty liver disease patients were characterized by hypertension

hyperlipidemia

hyperglycemia

abdominal obesity

which was defined as metabolic syndrome

and elevated serum aminotransferase and gamma-glutamyl transpeptidase.The result of lipid peroxidation analysis revealed increased serum concentration of oxidated glutathione and malonaldehyde and decreased reduced glutathione.Multiple linear regression analysis illustrated that there were parameters which were related to metabolic syndrome associated with non-alcoholic fatty liver disease

and the indexes of lipid peroxidation were significantly correlated with serum aminotransferase and gamma-glutamyl transpeptidase.Conclusions: Serum malonaldehyde

reduced and oxidated glutathione and GSH/GSSG ratio are closely related to serum aminotransferase and gamma-glutamyl transpeptidase level and may be ideal for disease activity evaluation and estimation.