Objective: To evaluate protective effects and possible mechanism of probucol on the kidney of aging rats induced by D-galactose.Methods:36 rats were divided randomly into 3 groups : negative control group(12 rats)

aging group(12 rats)

and probucol treatment group(12 rats).The sub-acute aging model rats were made by injecting D-gal into abdomen continuously(100 mg/kg

42 d).The morphological changes were observed.The activities of superoxide dismutase(SOD) and GSH-Px and the concentration of malondialdehyde(MDA) in the kidney were examined.Results:There were obvious glomerular dilatation

focal glomeru-lonephritis

tubular dilatation

part of the tubular atrophy and tubulointerstitial fibrosis in model groups.These changes were remarkably relieved in probucol treatment group.The activities of SOD and GSH-Px in model group were decreased

and the concentration of MDA was increased.In comparison

the activities of SOD and GSH-Px in treatment group were significantly increased

and the concentration of MDA was decreased(P<0.05).Conclusion:Probucol can decrease the level of MDA and increase the activities of SOD and GSH-Px

and suppress oxidative stress injury

so it has anti-aging effects.