儿童抗癫痫药高敏综合症20例临床分析

汤春辉; 田云粉

doi:10.13406/j.cnki.cyxb.2011.02.027

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儿童抗癫痫药高敏综合症20例临床分析

临床研究 | 更新时间：2024-01-17

- 儿童抗癫痫药高敏综合症20例临床分析
- Clinical analysis of antiepileptic drug hypersensitivity syndrome on 20 children
- 重庆医科大学学报 2011年36卷第2期页码：228-229
- 作者机构：
  
  云南省第一人民医院儿科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.02.027
  中图分类号： R742.1
- 纸质出版日期：2011，
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[1]汤春辉,田云粉.儿童抗癫痫药高敏综合症20例临床分析[J].重庆医科大学学报,2011,36(02):228-229.

TANG Chun-hui, et al. Clinical analysis of antiepileptic drug hypersensitivity syndrome on 20 children[J]. Journal of Chongqing Medical University, 2011,36(2):228-229.
[1]汤春辉,田云粉.儿童抗癫痫药高敏综合症20例临床分析[J].重庆医科大学学报,2011,36(02):228-229. DOI： 10.13406/j.cnki.cyxb.2011.02.027.

TANG Chun-hui, et al. Clinical analysis of antiepileptic drug hypersensitivity syndrome on 20 children[J]. Journal of Chongqing Medical University, 2011,36(2):228-229. DOI： 10.13406/j.cnki.cyxb.2011.02.027.

摘要

目的:总结我院20例诊断为抗癫痫药高敏综合征（Antiepileptic drug hypersensitivitysyndrome

AHS）患儿的临床特征、治疗方法及所用抗癫痫药

提高对本病的认识

为临床救治工作提供参考。方法:回顾性分析我院2000年1月至2010年4月诊断为AHS患儿的临床资料。结果:20例患儿中其中19例服用的是含芳香环抗癫痫药物

仅1例服用非芳香族抗癫痫药

所有患儿均有皮疹和发热。结论:AHS的临床表现各异

极易引起误诊

对儿童危害更大

故有必要充分认识AHS。芳香族抗癫痫药由于均含有苯环结构

易致AHS

且同类药存在高频率的交叉反应。

Abstract

Objective: The clinical features

therapeutic method and antiepileptics of antiepileptic drug hypersensitivity syndrome(AHS) on 20 children were analyzed

it’s good for recognition and remedy of this kind of disease.Methods: The retrospective analysis was carried out on the clinical data of the children treated in our hospital from Jan 2000 to Apr 2010 who were diagnosed as AHS.Results: 19 of 20 children were treated with aromatic antiepileptic drugs and the other 1 was treated with non-aromatic antiepileptic drugs.All children suffered skin rash and fever.Conclusion: The clinical situation of AHS was different and it was easy to cause diagnostic errors.So it was necessary to recognize AHS fully to prevent further harm to the suffered children.The benzene ring in the molecular structure of aromatic antiepileptic drug was believed to be a cause of AHS

and altofrequent cross reaction was observed in congener drugs.

关键词

儿童抗癫痫药高敏综合征

Keywords

childrenantiepileptic drughypersensitivity syndrome

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