皮下自控镇痛对食管癌术后患者血清免疫球蛋白的影响

熊章荣; 张在空; 刘预; 羽平; 谢臣明; 蔡华荣; 唐延先

doi:10.13406/j.cnki.cyxb.2011.02.017

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皮下自控镇痛对食管癌术后患者血清免疫球蛋白的影响

临床研究 | 更新时间：2024-01-17

- 皮下自控镇痛对食管癌术后患者血清免疫球蛋白的影响
- Effect of postoperative patient-controlled subcutaneous analgesia on serum immunoglobulin in patients with esophageal cancer
- 重庆医科大学学报 2011年36卷第2期页码：206-209
- 作者机构：
  
  1. 重庆市肿瘤研究所麻醉科
  2. 重庆市肿瘤研究所胸外科
  3. 重庆市肿瘤研究所中心实验室
- 作者简介：
- 基金信息：
  
  重庆市卫生局科研资助课题（编号:2008-2-279）
- DOI：10.13406/j.cnki.cyxb.2011.02.017
  中图分类号： R614
- 纸质出版日期：2011，
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[1]熊章荣,张在空,刘预,羽平,谢臣明,蔡华荣,唐延先.皮下自控镇痛对食管癌术后患者血清免疫球蛋白的影响[J].重庆医科大学学报,2011,36(02):206-209.

XIONG Zhang-rong, et al. Effect of postoperative patient-controlled subcutaneous analgesia on serum immunoglobulin in patients with esophageal cancer[J]. Journal of Chongqing Medical University, 2011,36(2):206-209.
[1]熊章荣,张在空,刘预,羽平,谢臣明,蔡华荣,唐延先.皮下自控镇痛对食管癌术后患者血清免疫球蛋白的影响[J].重庆医科大学学报,2011,36(02):206-209. DOI： 10.13406/j.cnki.cyxb.2011.02.017.

XIONG Zhang-rong, et al. Effect of postoperative patient-controlled subcutaneous analgesia on serum immunoglobulin in patients with esophageal cancer[J]. Journal of Chongqing Medical University, 2011,36(2):206-209. DOI： 10.13406/j.cnki.cyxb.2011.02.017.

摘要

目的:评价皮下自控镇痛对食管癌术后患者免疫球蛋白的影响。方法:选取我院拟行食管癌根治手术的病人60例

随机分为皮下自控镇痛组（Patient controlled subcutaneous analgesia

PCSA）组

n=20、静脉自控镇痛组（Patient controlled intravenousanalgesia

PCIA）组

n=20和硬膜外自控镇痛组（Patient controlled epidural analgesia

PCEA）组

n=20。术毕以电子镇痛泵分别行皮下、静脉、硬膜外自控镇痛

行术后6、12、18、24 h及48 h的镇痛评分（Visual analogue scale

VAS）;采用免疫比浊法检测麻醉前（基础值T1）

术毕（T2）、术后第1天（T3）、术后第2天（T4）、术后第5天（T5）免疫球蛋白IgAI、gG和IgM的水平。结果:术前3组患者免疫球蛋白IgAI、gG和IgM差异无显著性（P>0.05）。术后3组患者IgAI、gM较术前无显著性下降（P>0.05）

而IgG术毕较术前下降（P<0.05）

术后1、2、5 d也较术前下降（P<0.01）。组间比较:PCSA组分别与PCIA组、PCEA组相比

免疫球蛋白IgA、IgG和IgM在各对应时间点差异无显著性（P>0.05）。结论:PCSA对食管癌术后患者血清免疫球蛋白的影响与PCIA、PCEA相同

对于食管癌术后镇痛

PCSA也是一种较好的选择。

Abstract

Objective:To study the effects of postoperative patient-controlled subcutaneous analgesia on the levels of serum immunoglobulin in patients with esophageal cancer after operation.Methods:Sixty patients with esophageal cancer undergoing elective surgery were randomly divided into three groups: patient controlled subcutaneous analgesia group(PCSA group

n=20)

patient controlled intravenous analgesia group(PCIA group

n=20)

and patient controlled epidural analgesia group(PCEA group

n=20).VAS scores were evaluated at 6

24 h and 48 h after operation respectively.Blood samples were collected before anesthesia(T1)

at the end of surgery(T2) and 1 d(T3)

2 d(T4) and 5 d(T5) after surgery for measurement of the levels of immunoglobulin.Results: There were no significantly differences of serum immunoglobulin IgA

IgG and IgM before anesthesia(T1) in each groups.After surgery

serum IgA

IgM levels were not significantly decreased than before anesthesia(P>0.05).However

serum IgG levels were significantly decreased at the end of surgery(T2) in the three groups(P<0.05) and at 1

2 d and 5 d after surgery in the three groups(P<0.01).There were no significant differences in serum IgA

IgG and IgM levels in PCSA and PCIA and PCEA groups at any time point after operation(P>0.05).Conclusion:There is similitude among PCSA and PCIA and PCEA groups on serum immunoglobulin IgA

IgG and IgM.PCSA is a good choice for patients with esophageal cancer surgery.

关键词

皮下自控镇痛食管癌免疫球蛋白

Keywords

patient controlled subcutaneous analgesiaesophageal cancerimmunoglobulin

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