血小板分布宽度作为新型血小板活化特异性标志物的评价

李月; 代震宇; 张德纯

doi:10.13406/j.cnki.cyxb.2011.02.011

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血小板分布宽度作为新型血小板活化特异性标志物的评价

技术与方法 | 更新时间：2024-01-17

- 血小板分布宽度作为新型血小板活化特异性标志物的评价
- Evaluation on platelet distribution width as a novel specific marker of platelet activation
- 重庆医科大学学报 2011年36卷第2期页码：200-202
- 作者机构：
  
  1. 重庆医科大学附属第二医院检验科
  2. 重庆医科大学附属第一医院骨科
  3. 重庆医科大学基础医学院病原生物学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.02.011
  中图分类号： R446.11
- 纸质出版日期：2011，
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[1]李月,代震宇,张德纯.血小板分布宽度作为新型血小板活化特异性标志物的评价[J].重庆医科大学学报,2011,36(02):200-202.

LI Yue, et al. Evaluation on platelet distribution width as a novel specific marker of platelet activation[J]. Journal of Chongqing Medical University, 2011,36(2):200-202.
[1]李月,代震宇,张德纯.血小板分布宽度作为新型血小板活化特异性标志物的评价[J].重庆医科大学学报,2011,36(02):200-202. DOI： 10.13406/j.cnki.cyxb.2011.02.011.

LI Yue, et al. Evaluation on platelet distribution width as a novel specific marker of platelet activation[J]. Journal of Chongqing Medical University, 2011,36(2):200-202. DOI： 10.13406/j.cnki.cyxb.2011.02.011.

摘要

目的:探讨血小板分布宽度（Platelet distribution width

PDW）作为血小板活化指标的可行性研究。方法:应用Sysmex XE-2100全自动血细胞分析仪测定100份本院体检的25

0周岁正常人群和100名已确诊的血小板活化患者的血常规标本的平均血小板体积（Mean platelet volume

MPV）与PDW值。随机选取本院患者血常规标本100份

在采血后的1、2、3、4 h检测MPV与PDW值。结果:已确诊的血小板活化患者的MPV与PDW值均显著高于正常人群MPV与PDW值（P

0.001）。血样本采集后的12、、3、4h时的MPV值升高

但PDW值均值逐渐降低。采血后4h的MPV值明显高于采血后1h的MPV检测值（P

0.05）

但4 h时的PDW值明显低于1 h时的PDW检测值（P

0.01）。结论:MPV与PDW检测简单

在血小板活化时显著增高。血小板发生储存损伤时

PDW值却降低

故PDW是比较特异的血小板活化指标。

Abstract

Objective: To evaluate the feasibility of platelet distribution width(PDW) for platelet activation.Methods: Mean platelet volume(MPV) and PDW in three groups of persons

using Sysmex XE-2100 hematology analyzer

were measured.The first group were healthy control subjects.The second study group were patients with established platelet activation.The third group were randomly chosen patients

whose MPV and PDW were assessed based on the effect of storage time.Results: There was a significant increase in MPV and PDW in patients with established platelet activation compared with healthy control subjects(P<0.001).A significant increase was observed in MPV(P<0.05)

but decrease in PDW over storage time(P<0.01).Conclusion: PDW is a more specific marker of platelet activation than MPV is

and the detection method with PDW is simple and accurate.PDW increases obviously during platelet activation

whereas it decreases during simple platelet swelling over storage time.

关键词

血小板分布宽度血小板活化

Keywords

platelet distribution widthplatelet activation

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