Objective: To investigate the variation of bone morphogenetic protein-7(BMP-7)before and after "Jie Gu Yi Hao" treatment in the radius fracture of rabbit.Methods: 56 rabbits of New Zealand were randomly assigned into 2 groups

experimental group and control group.3 mm-long bone defect were taken in both radii of each rabbit.The experimental group were treated by "Jie Gu Yi Hao"

while the control group was not treated.After 2

4

6 w

sacrifice the experimental animal.Then

assess the fracture healing through X-ray and HE.After 5

7

9 d and 2

3 w

observe the changes of BMP-7 through RT-PCP and immunohistochemistry.Results: X-ray shows: experimental group’s bone callus appeared earlier and having more quantity bone callus.The experimental group’s fibronectin and osteoblast occurs earlier than control group through HE

also have more callus than control group.Finally

do statistical analysis as the mean comparison of two samples’ test into gray value of RT-PCR and MOD of immunohistochemistry.The results show that the difference is statistically significant.Conclusion: "Jie Gu Yi Hao" can promote fracture healing by improving the expression of BMP-7.