Objective:To investigate the relationship of one-hour postloade plasma glucose with inflammatory factor in different glucose tolerance.Methods:the subjects were divided into four groups:type 2 diabetes(T2DM)

impaired glucose tolerance(IGT)

normal glucose tolerance(NGT) with 1 hPG higher than 8.0 mmol/L and normal glucose tolerance with 1 hPG lower than 8.0 mmol/L.Compare the general data and Hs-CRP、TNF-α in each group.Results:(1)TNF-α and Hs-CRP were upgraded from NGT to T2DM.The levels of TNF-α and Hs-CRP in NGT which 1 hPG exceeding 8.0 mmol/L were significantly higher than that in NGT with 1 hPG lower than 8.0 mmol/L(P<0.01and P<0.05) and similar with IGT(P>0.05).(2) 1 hPG were positively correlated with TNF-α、TG、 SBP、 HsCRP

(r=0.405;r=0.388;r=0.310;all P<0.01

r=0.183;P<0.05)and negatively with HDL-C(r=-0.302;P<0.01).The correlation of SBP、HDL-C and TG with 1 hPG were harder than that with 2 hPG.(3) Multiple regression analysis showed that TG、TNF-α and SBP were independent related factors influencing 1 hPG.Conclusion:There were the change of Hs-CRP and TNF-α of inflammatory factors and there maybe the presence of abnormal inflammatory reaction in normal glucose tolerance when 1 hPG exceed 8.0 mmol/L

which is correlated with development of IGT or diabetes and vascular lesion and we can’t ignore them when we screen the population inclinable to diabetes.