Objective:To study the association between polymorphisms of rs17235409A/G、rs17235416TGTG/(-) in NRAMP1 gene and susceptibility to tuberculosis in Han nationality of Chongqing.Methods:The case-control study was adopted.According to the TB diagnosis standard(GB 15987-1995)

100 TB patients with positive result on sputum smear test were chosen from the tuberculosis hospital in Chongqing.106 healthy individuals without history of tuberculosis and other diseases were selected as controls.Genotyping of NRAMP1 rs17235409A/G and rs17235416TGTG/(-) was done by PCR-RFLP.The calculation and analysis of the association between polymorphisms of the two sites and susceptibility to tuberculosis were performed by SAS 8.2.Results:The frequencies of NRAMP1 rs17235409 GG、GA+AA genotypes in cases were 67.00%、33.00%

which were 87.34%、12.26% in controls

the difference between the case and control had statistically significance(χ2=12.694 8

P<0.05).NRAMP1rs17235409 GA+AA genotypes had a significant increased risk of tuberculosis(OR=3.523 5

OR95%CI:1.762 3～7.044 9) compared to GG genotype.The frequencies of NRAMP1rs 17235416TGTG/(-) polymorphism had statistically significant difference between the case and control(χ2=7.377 3

P<0.05)

rs17235409 TGTG/(-)+TGTG(-)/(-) genotypes had a significant increased risk of tuberculosis(OR=2.340 2

OR95%CI:1.267 0～4.322 2) compared to TGTG/TGTG genotype.Conclusion:The NRAMP1 rs17235409A/G and rs17235416TGTG/(-) polymorphisms were possibly associated with susceptible to tuberculosis in Han nationality of Chongqing.NRAMP1 rs17235409A allele and rs17235416TGTG/(-) allele were possibly the risk factors of tuberculosis in Han nationality of Chongqing.