Objective:To summarize the clinical features of hand-foot-mouth disease(HFMD) complicated with central nervous system damage

and analysis its risk factors.Methods:We summarized the clinical features by retrospective analysis of 926 cases of HFMD in our hospital

as well as risk factors analysis by Logistic regression.Results:A total of 52 children complicated with central nervous system damage in 874 HFMD patents(5.9%).The sex ratio was 2.1:1.The average age was(2.5± 2.1) year

lower than normal HFMD patients(P<0.05).Heat rate was 51.9%

higher than normal HFMD patients(P<0.05).The typical symptoms of nervous system damage were headache

vomiting

easily frightened

lethargy

neck resistance

body shake

myoclonus

weakness or paralysis and ataxia and so on.24 children have abnormal white blood cell count

16 children have higher blood sugar

which were higher than normal HFMD children(P <0.05).EV71-positive rate was 72.7%.49 cases were cured

1 cases left over the left upper limb weakness

2 patients died of cardiac arrest.Mortality is also higher than normal HFMD patients(P<0.05).Risk factor analysis showed that the smaller children

usually grandparents care

low average monthly household income

are the independent risk factor for central nervous system damage in HFMD.Conclusion:HFMD children with high fever

in a daze

shaking time are suspected to be a high degree of central nervous system damage;smaller age of months

cared by grandparents

low income families are the independent risk factor for central nervous system damage in HFMD

which should be paid more attention to.