Objective:Toevaluate syntheticallythe association between bradykinin β2 receptor(BDKRβ2)gene-58T/C polymorphism and the risk of hypertension with Meta-analysis. Methods :In electronic databases

the literatures of case-control trials of the relation between BDKR β2 gene-58T/C polymorphism and the hypertension risk were searched

which met the inclusion criteria.Statistical analysis was performed with RevMan 5.0 and SPSS 13.0 to investigate heterogeneity;then suitable models were selected for data combination and effect evaluation and to undertake the analysis of ethnic subgroups and the evaluation of publication bias. Results: Totally

10 literatures

12 studies

1 736 cases and 1 682 controls were included. The Meta analysis showed that the hypertension risk of carriers of BDKRβ2 CC genotype was 1.36 times as much as the risk of carriers of CT or TT genotype (P=0.03). Japanese

Chinese Han and African-American CC genotype were related with the hypertension risk (P<0.05);but the association between Caucasian and the hypertension risk was indefinite in the subgroups analysis (P=0.85). Conclusion:The CC genotype of BDKRβ2-58T/C polymorphism might increase the hypertension risk

but this conclusion is notably affected by ethnic differences.