Objective:To investigate the risk factors

pathogen distribution

and drug sensitivity of neonatal ventilator-associated pneumonia (VAP). Methods:The clinical data of all mechanical ventilated (≥48 h)patients who were admitted to the neonatology of Children’s Hospital of Chongqing Medical University from may 2006 to may 2009 were collected. The incidence of VAP

the risk factors and pathogenic bacteria culture results were retrospectively analyzed. Results:The morbidity of VAP was 46.30%. Univariate analysis showed that the time for mechanical ventilation

birth weight

gestational age

and the number of tracheal intubation were all related to the occurrence of VAP. Multivariate Logistic regression analysis showed that the time for mechanical ventilation was an independent risk factor for VAP. 116 strains of bacterium were found from the total 94 patients with VAP

of which 75 strains were Gram-negative bacilli;27 strains were gram-positive cocci;14 strains were fungi. The most common pathogens were Klebsiella pneumoniae

Acinetobacter baumannii and Pseudomonas aeruginosa. The antibiotics-sensitivity showed multidrug resistance to most commonly used antibiotics

but sensitivity to only a few antibiotics. Conclusion:The morbidity of VAP was very high.The incidence of VAP was related to the time for mechanical ventilation

birth weight

gestational age

the number of endotracheal intubation and other factors. Comprehensive treatment should be used to prevent the incidence of VAP. The main VAP pathogenic bacterium was gram negative bacilli. The multi-drug resistant pathogenic bacteria were common. So the rational use of antibiotics according to drug sensitivity is important in treating VAP.