Objective:To observe the effect of azithromycin on intragastric pressure(IGP) and gastric electrical slow wave

and to explore the dependent nerve and receptor.Methods:Forty-eight SD rats were used for experiments.Animals received intravenous injection of different doses azithromycin or normal saline(1 ml).Both IGP and gastric electrical activity were recorded by BL-410 Biological signal recording system(n=30).Pretreatment of atropine was intraperitoneal injection

and then high-dose azithromycin was injected and IGP was recorded(n=6).Pretreatment of vagotomy was carried out

and then high-dose was used and IGP and gastric electrical activity was recorded(n=12).Results:Intravenous medium dose azithromycin(75 mg/kg) and high dose azithromycin(150 mg/kg) caused the increase of IGP

the change rate of IGP induced by medium dose had significance after 20 minutes

the change of high dose appeared at the 10th min.Different doses had no obvious influence on gastric electrical slow wave amplitude and frequency.No obvious changes in both IGP and gastric electrical activity was observed in normal saline.Atropine almost completely blocked the effect of azithromycin on IGP.Pretreatment of subdiaphragmal vagotomy affected the increase of IGP induced by azithromycin

IGP discreased obviously

but gastric electrical activity were not changed.Conclusion:Intravenous azithromycin could increase IGP

this effect might rely on vagus and cholinergic receptor;Azithromycin might have no obvious effect on gastric electrical slow wave amplitude and frequency.