Objective:To investigate the relationship between serum alanine aminotransferase levels(ALT) and glycometabolism

lipometabolism

body weight index in fatty liver disease.Methods:A total of 17300 subjects who got medical health checkup in our medical examination center in 2008

diagnosed as fatty liver through ultrasound imaging

were enrolled in the study.Statistical analysis was given on the relationship between ALT and lipid(total cholesterol

triglyceride

high density lipoprotein

low density lipoprotein)

fasting plasma glucose(FPG)

body weight index(BMI).Results:The levels of FPG

lipid

BMI in abnormal ALT group were higher than those in normal ALT group

in which difference in lipid and BMI has statistical significance;the abnormal rate of lipid and BMI between two groups has significant difference also

except the abnormal rate of FPG has no significance.Moreover

in the multiple stepwise regression analysis

there were statistically significant correlations between ALT levels and high density lipoprotein

low density lipoprotein

BMI.Conclusion:Abnormality of ALT is not only common clinical manifestation of fatty liver

but also the important marker of inflammation of fatty liver.ALT levels of nonalcoholic fatty liver is related with obesity and hyperlipid.It may ameliorate the progression of the inflammation of fatty liver and prevent the liver failure by keeping fit weight and lowering of body lipid.