普罗布考自微乳化释药系统大鼠体内药动学研究

马俐丽; 朱照静

doi:10.13406/j.cnki.cyxb.2010.08.044

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普罗布考自微乳化释药系统大鼠体内药动学研究

技术与方法 | 更新时间：2024-01-17

- 普罗布考自微乳化释药系统大鼠体内药动学研究
- Pharmacokinetics of probucol self-microemulsifying drug delivery system in rats
- 重庆医科大学学报 2010年35卷第8期页码：1232-1234
- 作者机构：
  
  重庆医科大学药学院药剂教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.08.044
  中图分类号： R965
- 纸质出版日期：2010，
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[1]马俐丽,朱照静.普罗布考自微乳化释药系统大鼠体内药动学研究[J].重庆医科大学学报,2010,35(08):1232-1234.

MA Li-li, et al. Pharmacokinetics of probucol self-microemulsifying drug delivery system in rats[J]. Journal of Chongqing Medical University, 2010,35(8):1232-1234.
[1]马俐丽,朱照静.普罗布考自微乳化释药系统大鼠体内药动学研究[J].重庆医科大学学报,2010,35(08):1232-1234. DOI： 10.13406/j.cnki.cyxb.2010.08.044.

MA Li-li, et al. Pharmacokinetics of probucol self-microemulsifying drug delivery system in rats[J]. Journal of Chongqing Medical University, 2010,35(8):1232-1234. DOI： 10.13406/j.cnki.cyxb.2010.08.044.

摘要

目的:考察普罗布考（Probucol

PB）自微乳化释药系统（Probucol self-microemulsifying drug delivery system

PB-SMEDDS）在大鼠体内的药动学。方法:以大鼠为模型动物

PB混悬液为参比

按自身对照单剂量双周期交叉给药方案

对PB-SMEDDS进行药动学研究。采用高效液相色谱法检测血药浓度

3P97药动学软件处理数据。结果:PB-SMEDDS属于双隔室模型（权重系数为1/C2）

Cmax为6.72μg/ml

tmax为8.58h

AUC0～96h为253.98（μg.h）/ml

AUC0～96h为PB混悬液的19.08倍。结论:PB-SMEDDS可显著提高PB的口服生物利用度。

Abstract

Objective:To investigate the pharmacokinetics of probucol(PB)self-microemulsifying drug delivery system(PB-SMEDDS) in rats.Methods:Rats were used as the models.With PB suspension as control

double cycle crossover with single oral dose was performed to investigate the pharmacokinetics of PB-SMEDDS.The HPLC method was established to detect drug concentration in the rat plasma

and the obtained data were processed with 3P97 software.Results:The plasma concentration-time profiles of PB-SMEDDS conformed to a two-compartment model(the coefficient weight is 1/C2).Cmax

tmax and AUC0～96h were 6.72μg/ml

8.58 h and 253.98(μg.h)/ml

respectively.The AUC0～96h of PB-SMEDDS was 19.08 times of PB suspension.Conclusion:PB-SMEDDS could improve the oral bioavailability of PB significantly.

关键词

普罗布考自微乳化释药系统高效液相色谱药动学

Keywords

probucolSelf-microemulsifying drug delivery systemHPLCpharmacokinetics

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