Objective:To investigate the impact of recombinant human epidermal growth factor(rhEGF)on a number of parameters following Epi-lasik surgery.Methods:Two hundreds cases with myopia(396 eyes)were randomly divided into two groups:100 cases in both groups.Epi-lasik was performed on these patients.Patients receiving non-steroid

corticosteroid

antibiotic and artificial-tears eye drops following Epi-lasik were categorized into control groups.Patients receiving rhEGF eye drops 3 days before and after Epi-lasik in combination with postoperative non-steroid

corticosteroid

antibiotic and artificial-tears eye drops were categorized into rhEGF group. Breakup time of tear film(BUT)was evaluated before and after the operation.Haze development

the rate of the flap melting

healing time of melted flap

postoperative irritation

residual refractive error and visual acuity were evaluated after the operation.Results:There was no difference between control group and rhEGF group concerning the preoperative spherical equivalent

preoperative BUT

the rate of postoperative flap melting

residual refractive error 6 months after Epi-lasik.However

there was significant difference between control group and rhEGF group as regard the following parameters:postoperative BUT

control group

10.43±1.08 s

rhEGF group 12.21±1.43 s

P<0.01;Haze rate:control group

33%

rhEGF group

12%

P<0.01;healing time of melted flap:control group

6.50±1.941D

rhEGF group

4.58±0.684D

P<0.01;postoperative severe irritation:control group

25%

rhEGF group 0%

P<0.01;visual acuity 6 months after Epi-lasik

control group≥4.9

90.5%

rhEGF group≥4.9

96.5%

P<0.05.Conclusion:Instillation of rhEGF could greatly improve the prognosis of the patients after Epi-lasik.