Toll样受体4在小儿扩张型心肌病外周血单核细胞的表达及临床意义初探

谢盛慧; 钟家蓉; 张静; 李欣

doi:10.13406/j.cnki.cyxb.2010.08.024

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Toll样受体4在小儿扩张型心肌病外周血单核细胞的表达及临床意义初探

临床研究 | 更新时间：2024-01-17

- Toll样受体4在小儿扩张型心肌病外周血单核细胞的表达及临床意义初探
- Study on the expression of Toll-like receptor 4 in peripheral blood monocytes in children with dilated cardiomyopathy and its clinical significance
- 重庆医科大学学报 2010年35卷第8期页码：1241-1244
- 作者机构：
  
  重庆医科大学附属儿童医院心内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.08.024
  中图分类号： R725.4
- 纸质出版日期：2010，
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[1]谢盛慧,钟家蓉,张静,李欣.Toll样受体4在小儿扩张型心肌病外周血单核细胞的表达及临床意义初探[J].重庆医科大学学报,2010,35(08):1241-1244.

XIE Sheng-hui, et al. Study on the expression of Toll-like receptor 4 in peripheral blood monocytes in children with dilated cardiomyopathy and its clinical significance[J]. Journal of Chongqing Medical University, 2010,35(8):1241-1244.
[1]谢盛慧,钟家蓉,张静,李欣.Toll样受体4在小儿扩张型心肌病外周血单核细胞的表达及临床意义初探[J].重庆医科大学学报,2010,35(08):1241-1244. DOI： 10.13406/j.cnki.cyxb.2010.08.024.

XIE Sheng-hui, et al. Study on the expression of Toll-like receptor 4 in peripheral blood monocytes in children with dilated cardiomyopathy and its clinical significance[J]. Journal of Chongqing Medical University, 2010,35(8):1241-1244. DOI： 10.13406/j.cnki.cyxb.2010.08.024.

摘要

目的:观察扩张型心肌病（Dilated cardiomyopathy

DCM）患儿外周血单核细胞Toll样受体4（Toll-like receptor4

TLR4）表达情况

初步探讨TLR4在小儿扩张型心肌病发病中的作用

为临床治疗小儿扩张型心肌病提供新的思路。方法:应用流式细胞术检测18例扩张型心肌病患儿及17例健康小儿外周血单核细胞TLR4的表达水平。结果:DCM患儿外周血单核细胞TLR4的平均荧光强度（Mean fluorescence intensity

MFI）明显高于健康小儿（[34.67±7.61）v（s22.62±4.28）

P<0.01]

并且MFI的高低与心衰程度相关

在心功能Ⅲ/Ⅳ级的DCM患儿表达明显高于心功能Ⅰ/Ⅱ级患儿

增高的程度与患儿左室射血分数（Left ventricular ejection fraction

LVEF）的值呈负相关

与心胸比例成正相关。结论:TLR4与小儿DCM的发病有关

且与心脏大小和心功能衰竭有关。

Abstract

Objective:To provide a new way for the management of children with dilated cardiomyopathy(DCM)

by observing the expression of Toll-like receptor 4(TLR4)in peripheral blood monocytes in children with DCM

and exploring the role of TLR4 in children with DCM.Methods:Expression of TLR4 in peripheral blood monocytes from 17 controls

and 18 children with DCMwas compared with the use of flow cytometry.Results:The mean fluorescence intensity(MFI)of TLR4 in peripheral blood monocytes was significantly higher in children with DCMcompared to controls((34.67±7.61)vs(22.62±4.28)

P<0.01).Moreover

the MFI levels were correlated with the severity of heart failure

and the MFI of DCMwith functional class Ⅲ/Ⅳheart failure was obviously higherthan that with functional classⅠ/Ⅱ.Negative correlation was observed between TLR4 expression and left ventricular ejection fraction;and positive correlation was observed between TLR4 expression and cardiothoracic ratio.Conclusion:TLR4 is related to the pathogenesis of DCM

so as the heart size and heart failure.

关键词

小儿扩张型心肌病Toll样受体4流式细胞术

Keywords

childrendilated cardiomyopathyToll-like receptor4flow cytometry

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