Objective:To discuss the preventive function of passive movement and electric stimulation on rats with disuse osteoporosis. Methods:Through cutting the sciatic nerve and femoral nerve of experimental rats

we made an animal model of disuse osteoporosis

and divided them into five groups:the pseudo operation group

the denervation group(DG)

denervation with passive movement group(PMG)

denervation with electric stimulation group(ESG)

and denervation with passive movement and electric stimulation group(PMESG).Then the changes of biochemistry indicators of bone metabolism were observed in all groups.Results:Compared with sham group

the Bone gla protein(BGP)value in the other groups were markedly lower(P<0.01).The tartrate-resistant acid phosphatas(eTRACP)value in the other groups all had a significant increase

but insignificant in statistics(P>0.05).Compared with DNG

the BGP value in the other groups increased

especially that the BGP in the PMESG was significantly increased(P<0.05)

however

the TRACP value in the other groups all exhibited a very significant reduction(P<0.01).Conclusion:Denervation of rats’sciatic and femoral nerves can make bone formation decrease and bone absorption increase

but passive movement and electric stimulation can inhibit the decrease of bone formation and the increase of bone absorption

which shows that passive movement and electric stimulation can prevent disuse osteoporosis made by denervation on a certain extent.