Objective:To investigate the clinical features

treatment and outcomes of systemic lupus erythematosus(SLE)in the elderly. Methods:The Clinical manifestation

laboratory data and treatment effects in the elderly with SLE

were reviewed and compared with those report from the young and middle-aged in the same period.Results:Compared with middle-youth-aged group

dyspnea of first symptoms was obviously more(P<0.01)

butterfly-wings erythema and photo sensetativity of first symptoms were less(P<0.05).Development as the illness

serositis

heart damage

lung damage

and damage in nerval systemwere mor(eP<0.05)

but butterfly-wings erythema

alopecia and fever were less(P<0.05).In laboratory features

hyperlipemia was more(P<0.01)

and positive anti-ds-DNA

high erythrocyte sedimentation rate(ESR)and low white blood cell were les(sP<0.05).On the other hand

hypertension and osteoporosis of comorbidities were more(P<0.01)

intermittent intravenous cyclophosphamide(CTX)was less commonly used(P<0.05).Conclusion:SLE in the elderly is characterized by long course of disease which is occult in onset

and it is easy to be misdiagnosed.The side effect shoud be monitored closely.