超顺磁性异烟肼聚乙二醇-聚乳酸共聚物微球制备工艺及体外药物释放研究

周恒; 黄华; 罗聪; 康权

doi:10.13406/j.cnki.cyxb.2010.07.048

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超顺磁性异烟肼聚乙二醇-聚乳酸共聚物微球制备工艺及体外药物释放研究

技术与方法 | 更新时间：2024-01-17

- 超顺磁性异烟肼聚乙二醇-聚乳酸共聚物微球制备工艺及体外药物释放研究
- Study on the preparation and in vitro release characteristics of super paramagnetic isoniazid sulfate-loaded PELA microsphere
- 重庆医科大学学报 2010年35卷第7期页码：1032-1037
- 作者机构：
  
  1. 重庆医科大学药学院药剂教研室
  2. 重庆医科大学附属儿童医院骨科实验室
- 作者简介：
- 基金信息：
  
  国家自然科学基金（编号:30973062）;中国博士后科学基金（编号:20080430754）;重庆市卫生局重点课题（编号:渝卫科教[2007]1号）
- DOI：10.13406/j.cnki.cyxb.2010.07.048
  中图分类号： R943
- 纸质出版日期：2010，
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[1]周恒,黄华,罗聪,康权.超顺磁性异烟肼聚乙二醇-聚乳酸共聚物微球制备工艺及体外药物释放研究[J].重庆医科大学学报,2010,35(07):1032-1037.

ZHOU Heng, et al. Study on the preparation and in vitro release characteristics of super paramagnetic isoniazid sulfate-loaded PELA microsphere[J]. Journal of Chongqing Medical University, 2010,35(7):1032-1037.
[1]周恒,黄华,罗聪,康权.超顺磁性异烟肼聚乙二醇-聚乳酸共聚物微球制备工艺及体外药物释放研究[J].重庆医科大学学报,2010,35(07):1032-1037. DOI： 10.13406/j.cnki.cyxb.2010.07.048.

ZHOU Heng, et al. Study on the preparation and in vitro release characteristics of super paramagnetic isoniazid sulfate-loaded PELA microsphere[J]. Journal of Chongqing Medical University, 2010,35(7):1032-1037. DOI： 10.13406/j.cnki.cyxb.2010.07.048.

摘要

目的:制备超顺磁性异烟肼聚乙二醇-聚乳酸共聚物（Poly（ethylene glycol）-co-poly（d

l-lactide）

PELA）微球（SPI-PELA-MS）

优化其制备工艺

考察其在振荡磁场影响下的体外释放。方法:用化学共沉淀法合成超顺磁性Fe3O4纳米粒

用复乳溶剂蒸发法制备SPI-PELA-MS。考察均质机转速、内水相与油相体积比、PELA浓度等不同因素对微球的影响

通过正交实验优化制备工艺

并对其粒径分布、形态、和体外释放性质进行了研究。结果:SPI-PELA-MS最优工艺处方为:均质机转速13000r/min、内水相与油相比1∶20、内水相中药物水溶液体积与磁流体体积比1∶2、PELA浓度40mg/ml、超声功率600W、PVA浓度1.5%。在体外释放中

通过外加振荡磁场的影响

能显著提高SPI-PELA-MS中药物的释放。结论:采用复乳溶剂蒸发法可成功制备SPI-PELA-MS

体外释放表明药物具有缓释功能

振荡磁场可以增加体系中药物的释放。

Abstract

Objective:To prepare super paramagnetic SPI-loaded PELA microsphere

study its release characteristics in vitro with the effect of oscillating magnetic fields.Methods:The nanospheres of super paramagnetic were prepared by chemical coprecipitation and then the super paramagnetic SPI-loaded PELA microspheres were prepared by double-emulsion/solvent evaporation method.Some factors affecting preparation technic

such as concentration of PVA

PELA concentration

speed of viscolizer and so on were studied.In addition

the drug release of super paramagnetic SPI-loaded PELA microsphere with the effect of oscillating magnetic fields was studied.Results: Factors for the optimal preparation technic included:speed of viscolizer of 13 000 r/min

inter water phase/oil phase of 1/20

volume ratio of water and magnetic fluid in inter water phase of 1/2

PELA concentration of 40 mg/ml

ultrasonic efficiency of 600 W

concentration of PVA of 1.5%.Oscillating magnetic field could improve the speed of drug release.Conclusion:Super paramagnetic SPI-loaded PELA microsphere were successfully prepared according to double-emulsion/solvent evaporation method.SPI-PELA-MS had the characteristics of sustained-release.The oscillating magnetic fields could promote drug release of SPI-PELA-MS.

关键词

异烟肼PELA超顺磁性微球振荡磁场

Keywords

IsoniazidPELASuper paramagnetic microspheresOscillating magnetic fields

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