Objective:To investigate the effect of naloxone combined with xing-nao-jing injection in rescuing acute severe alcoholism. Methods:117 with acute severe alcoholism

who were admitted to the department of emergency of the First Affiliated Hospital of the Chongqing Medical University between January 2006 and May 2008

were randomly divided into the X-group(the treatment of xing-nao-jing injection simply)

N-group(the treatment of naloxone simply)and XN-group(the treatment of naloxone combined with xing-nao-jing injection).Breathing frequency(BR)

systolic blood pressure(SBP)

the recovery time of temperature

and the wake-up time were monitored and recorded.Then BR

SBP

the diameter of pupil

SPO2

PaO2 and FiO2/PaO2 at 1

4 and 8 h after the treatment were recorded.Results:The recovery times of BR

SBP and temperature in XN-group were equal to those of N-group(P>0.05).The wake-up times in above-mentioned two groups were shorter than that in X-group

and the recovery times of BR and temperature were shorter than that in X-group.SBP of XN-group were better than that of N-group at 4 and 8 h after the treatment.PaO2/FiO2 of XN-group was better than that of N-group and X-group at 8 h after the treatment.Meanwhile the symptoms after the patients came around

including dizzy and headache

nausea and vomiting

palpitation and chest distress

were fewer in XN-group than those in N-group(P<0.05). Conclusion:In the process of rescuing acute severe alcoholism

there were synergistic effect between xing-nao-jing injection and naloxone.Breath and circulation could be recovered promptly and effectively by the treatment of naloxone combined with xing-nao-jing injection.And it could relieve the symptoms

with better effects than single use of xing-nao-jing injection or naloxone.