体外循环术致婴幼儿脑损害的研究

吴春; 魏光辉; 代江涛; 彭明清

doi:10.13406/j.cnki.cyxb.2010.07.027

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体外循环术致婴幼儿脑损害的研究

临床研究 | 更新时间：2024-01-17

- 体外循环术致婴幼儿脑损害的研究
- Study of brain damage by cardiopulmonary bypass in infants
- 重庆医科大学学报 2010年35卷第7期页码：1092-1095
- 作者机构：
  
  重庆医科大学附属儿童医院心胸外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.07.027
  中图分类号： R726.5
- 纸质出版日期：2010，
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[1]吴春,魏光辉,代江涛,彭明清.体外循环术致婴幼儿脑损害的研究[J].重庆医科大学学报,2010,35(07):1092-1095.

WU Chun, et al. Study of brain damage by cardiopulmonary bypass in infants[J]. Journal of Chongqing Medical University, 2010,35(7):1092-1095.
[1]吴春,魏光辉,代江涛,彭明清.体外循环术致婴幼儿脑损害的研究[J].重庆医科大学学报,2010,35(07):1092-1095. DOI： 10.13406/j.cnki.cyxb.2010.07.027.

WU Chun, et al. Study of brain damage by cardiopulmonary bypass in infants[J]. Journal of Chongqing Medical University, 2010,35(7):1092-1095. DOI： 10.13406/j.cnki.cyxb.2010.07.027.

摘要

目的:探讨体外循环术（Cardopulmonary bypass

CPB）致婴幼儿脑扰动系数、血清中S100、NSE和脑损害的关系。方法:随机选择1～2岁的非紫绀型先心病儿40例分为实验A、B组

BORN-BE无创脑水肿动态监护仪监测脑部扰动系数的变化

ELISA方法检测CPB期间血清中S100、NSE的水平。结果:A、B组患儿脑部扰动系数、S100和NSE在CPB开始至结束均显著增高（P<0.05）

术后均有显著下降（P<0.05）;CPB开始后同一时间A、B组脑部扰动系数、S100和NSE分别比较

B组中左、右侧脑部扰动系数、S100和NSE含量均显著高于A组（P<0.05）。结论:CPB致脑水肿损害可应用脑部扰动系数、血清中S100和NSE联合检测。

Abstract

Objective:To explore relation of Cerebral electric impedance coefficient

S100

neuron specific enolase(NSE)in serum and brain damage by the cardopulmonary bypass(CPB)in infants.Methods:40 children in 1～2-year-old who were diagnosed to be non-cyanotic congenital heart disease were selected chosen as experimental A and B group.The BOEN-BE No-injury Brain-edema-monitor was used to test Cerebral electric impedance coefficient.The selum concentrations of S100 and NSE in the different time of cardiopul-monary bypass(CPB)were measured with enzyme linked immunosorbent assa.Results:Cerebral electric impedance coefficient

S100 and NSE were significantly increased from the beginning to the end in CPB and significantly decreased gradually after operation in the dif-ferent time in A and B group(P<0.05);Cerebral electric impedance coefficient

S100 and NSE in B group were significantly increased that in A group(P<0.05).Conclusions:Cerebral electric impedance coefficient

S100 and NSE in serum can be used to test brain dam-age during the CPB.

关键词

体外循环术扰动系数S100NSE脑损害

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